Evaluation of Ointments within Wound Healing in an In Vivo Model.

Abstract

Fungi are a source of a variety of secondary metabolites of importance in different areas of biotechnology. Several compounds have been characterized with antioxidant, antimicrobial, and anti-inflammatory activity from fungi of the division of the Ascomycota, among which is the species, an endophyte fungus of pantropical distribution. In this study, we evaluated the effect of an ointment made withon the wound healing of BALB/c mice. The species was corroborated using a molecular marker Internal Transcribed Spacer (ITS1 and ITS4). The extracts and dust of the fungus were considered nontoxic as they caused a mortality of <15% in the nematode, and experimental ointments had no adverse effects on the skin of BALB/c mice. Wounds treated with theointments had 99.9-100% wound contraction after 17 days, which was similar to commercial healing (positive control). As such, the ointment ofis a natural alternative to improve wound healing.