Peer-reviewed veterinary case report
Epithelioid haemangiosarcoma in the ocular tissue of horses.
- Journal:
- Journal of comparative pathology
- Year:
- 2011
- Authors:
- Arenas-Gamboa, A M & Mansell, J
- Affiliation:
- Texas A&M University · United States
- Species:
- horse
Plain-English summary
This study looked at a rare type of cancer called epithelioid hemangiosarcoma (HSA) that affects the eye tissues of horses. The horses involved were around 20 years old when they were diagnosed. Under the microscope, the tumors appeared as solid groups of cells, with only a few small spaces that contained red blood cells, which hinted at their blood vessel origin. Special tests showed that the cancer cells had certain markers typical of blood vessel cells, but not those found in other types of cells. The findings highlight the unusual nature of this cancer in horses, but the abstract does not provide information on treatment outcomes.
Abstract
Haemangiosarcomas (HSAs) are malignant tumours of endothelial cell origin. Epithelioid HSA is a variant of the histologically conventional HSA that has little or no morphological evidence of a vascular origin and has been reported rarely in domestic animals. The following report documents six cases of equine epithelioid HSA occurring in the ocular tissues of horses with a mean age of 19.8 years at the time of diagnosis. Microscopically, all of the lesions consisted of solid sheets or cords of epithelioid cells with rare narrow clefts or small spaces containing erythrocytes that were often the only feature indicating a vascular origin. On immunohistochemistry, the neoplastic cells expressed vimentin, CD31 and factor VIII-related antigen, but not cytokeratin, indicating an endothelial nature.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21251669/