Peer-reviewed veterinary case report
Epidermal dysplasia and Malassezia infection in two West Highland White Terrier siblings: an inherited skin disorder or reaction to severe Malassezia infection?
- Journal:
- Veterinary dermatology
- Year:
- 2001
- Authors:
- Nett, C S et al.
- Affiliation:
- Clinic of Small Animal Internal Medicine
- Species:
- dog
Plain-English summary
Two 9-month-old West Highland White Terrier siblings were brought to the clinic because they were very itchy, had hair loss, and their skin was thickening. Tests showed they had a skin infection caused by a type of yeast called Malassezia, along with some skin changes. They were treated with a special medicated shampoo and two medications, which helped clear the infection and allowed their hair to start growing back, but they were still somewhat itchy. Further testing revealed they were allergic to house dust mites, storage mites, and Malassezia, so they began allergy treatment and stopped the previous medications. After a follow-up, their skin showed mild irritation, but the remaining itchiness was easily managed with topical treatments. Overall, the treatment was effective in resolving the infection and improving their condition.
Abstract
Two 9-month-old West Highland White Terrier siblings were referred to our clinic with pruritus, alopecia and lichenification. Cytological examination of Scotch tape strippings revealed Malassezia organisms and cocci. Skin biopsy specimens showed epidermal dysplasia. Treatment included bathing with a 2% miconazole/chlorhexidine-containing shampoo, orally administered ketoconazole (5 mg kg-1, every 12 h) and cloxacillin (25 mg kg-1 every 8 h). Six weeks later, the dermal infection had resolved and there was hair regrowth. However, the dogs were still moderately pruritic. Intradermal allergy testing was positive for house dust mites, storage mites and Malassezia. Immunotherapy was initiated, and treatment with ketoconazole and cloxacillin was stopped. Skin biopsies, which were performed in both dogs 4 months after the first presentation, revealed mild superficial perivascular dermatitis. The remaining mild facial pruritus was easily controlled with topical treatment. These two cases indicate that epidermal dysplasia might be an inflammatory or hypersensitivity reaction to the Malassezia infection or a result of excessive self-trauma, rather than a congenital keratinization disorder.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/11906654/