Peer-reviewed veterinary case report
Environmental modulation of anxiety-related neuronal activity and behaviors.
- Journal:
- Behavioural brain research
- Year:
- 2008
- Authors:
- Bilkei-Gorzó, András et al.
- Affiliation:
- Institute of Molecular Psychiatry · Germany
- Species:
- rodent
Abstract
Enkephalin-deficient knockout mice, a genetic model of enhanced anxiety responses, and wild-type controls were housed in two separate facilities on the same campus using different caging systems. Stress reactivity was evaluated in these animals using a zero-maze test followed by c-Fos expression analysis in limbic brain regions. Animals with genetically or pharmacologically enhanced anxiety reared and tested in the same facility displayed similar behavioral reactivity and c-Fos induction. However, we found much stronger anxiety-related behavioral responses and higher c-Fos levels when animals were house in individually ventilated cages, independent of their genetic background.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17904656/