Effect of vitamin D₃ overdose and calcium supplementation in experimental nephrolithiasis model.

Abstract

INTRODUCTION: There is little information in the literature relating supplementary oral usage of vitamin D and calcium to the development of kidney stones. OBJECTIVE: To evaluate the effect of high dose, 200 IU of vitamin D3 (V) with calcium supplementation (Ca). METHODS: Experimental model consists of insertion of pellets into the bladder of rats. V was administered for 30 days with or without Ca. The rats were divided in 6 groups: 1. Sham, 2. Pellets control; 3. V control; 4. Pellets + V; 5. Pellets + Ca and 6. Pellets + Ca + V. RESULTS: 50% and 17% decreases bladder stones formation in groups 5 and 6, p < 0.005 comparing with the group 2 were observed. There was no hypercalcemia or hypercalciuria in all groups. We observed a significant decrease in calciuria in group 6 (p = 0.03). CONCLUSION: The administration of the V associated with Ca significantly decreased the formation of stones and caused a significant reduction in urinary calcium, suggesting a protection in the lithogenic pathophysiology.