Peer-reviewed veterinary case report
Effect of topiramate on mechanical allodynia in neuropathic pain model in rats.
- Journal:
- Polish journal of pharmacology
- Year:
- 2004
- Authors:
- Wieczorkiewicz-Płaza, Anna et al.
- Affiliation:
- Department of Human Anatomy
- Species:
- rodent
Abstract
Topiramate, unlike gabapentin, lamotrigine and tiagabine, resembles phenytoin and carbamazepine since it had been used as an antinociceptive drug in empirical treatment of neuropathic pain in humans, before its systemic and planned research was conducted in animal models of pain. Chronic administration of topiramate, at the dose of 50 mg/kg/day, significantly diminished the mechanical sensitivity and shortened the period of allodynia in the Seltzer mononeuropathy model in rats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15156080/