Peer-reviewed veterinary case report
Effect of pentobarbital on pH and electrolyte levels after induced seizure in rats.
- Journal:
- Seizure
- Year:
- 2007
- Authors:
- Uribe-Escamilla, R et al.
- Affiliation:
- National Institute of Rehabilitation
- Species:
- rodent
Abstract
We studied the effects of high doses of pentobarbital (PB) and carbamazepine (CBZ) on electrolyte levels and pH in an epileptic animal model. Pentobarbital decreased Ca2+ and Na+ levels without pentylenetetrazole (PTZ). After this, Ca2+ and Na+ levels continued to decrease except when CBZ was used, which preserved the Ca2+ levels PTZ may have opposed effects on PB. Our results suggest that PB causes changes in electrolyte levels and pH, but these changes are diminished by CBZ.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17395499/