Peer-reviewed veterinary case report
Effect of lysosomotropic form of amphotericin B on functional state of phagocytes in experimental candidiasis.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2008
- Authors:
- Kurilin, V V et al.
- Affiliation:
- Research Center of Clinical and Experimental Medicine
- Species:
- rodent
Abstract
Effect of antifungal preparation amphotericin B and its lysosomotropic composition with dialdehyde-dextran on functional state of phagocytizing cells in the dynamics of granulomatous inflammation induced by C. albicans was studied on CBA mice. A stimulating effect of amphotericin B on the production of reactive oxygen species by peritoneal and bone marrow phagocytes was observed, while lysosomotropic form of the antibiotic did not stimulate generation of oxygen radicals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19513358/