Peer-reviewed veterinary case report
Effect of ethanol on sleep-awake state in sleep-disturbed rats.
- Journal:
- Biological & pharmaceutical bulletin
- Year:
- 2010
- Authors:
- Obara, Yoshihito et al.
- Affiliation:
- Department of Medicinal Pharmacology · Japan
- Species:
- rodent
Abstract
The present study was undertaken to investigate the effect of ethanol on the sleep-wake cycle in normal rats and sleep-disturbed rats. In normal rats, no significant difference was observed by ethanol in sleep latency, total awake time and total non-rapid eye movement (NREM) sleep time, except for total REM sleep time. On the other hand, in sleep-disturbed rats, ethanol at doses of 1 and 2 g/kg caused significant decreases in sleep latency and total wake time, and an increase in total NREM sleep time. In addition, ethanol showed a significant increase in delta activity in the sleep-disturbed model rat, different from triazolam. These results suggested that ethanol had not only a hypnotic but also a sleep-maintaining effect in sleep-disturbed rats at reasonable blood ethanol concentrations.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20460765/