Peer-reviewed veterinary case report
Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy.
- Journal:
- Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
- Year:
- 2017
- Authors:
- Karyakin, V B et al.
- Affiliation:
- Sechenov Institute of Evolutionary Physiology and Biochemistry
- Species:
- rodent
Abstract
We studied early alterations in the GABAergic system of the rat hippocampus in the lithium-pilocarpine model of epilepsy. Twenty-four hours after the pilocarpine treatment, a decrease in the number of calretinin-positive interneurons was observed in the CA1 field of the hippocampus, whereas the number of parvalbumin-positive interneurons remained unchanged. The decreased levels of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD67) and the membrane GABA transporter GAT1 were revealed using Western blot analysis. These data indicate an altered excitation/inhibition balance in the hippocampus with excitation dominance.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28429259/