Peer-reviewed veterinary case report
Early adaptive changes in chronic paraplegic mice: a model to study rapid health degradation after spinal cord injury.
- Journal:
- Spinal cord
- Year:
- 2008
- Authors:
- Ung, R-V et al.
- Affiliation:
- Neuroscience Unit · Canada
- Species:
- rodent
Abstract
STUDY DESIGN: Literature review. OBJECTIVE: To describe quantitatively some of most important anatomic, systemic, and metabolic changes occurring soon (one month) after spinal cord trauma in mice. SETTING: University Laval Medical Center. RESULTS: Significant changes in weight, mechanical and contractile muscle properties, bone histomorphometry and biomechanics, deep-vein morphology, complete blood count, immune cell count, lipid metabolism and anabolic hormone levels were found occurring within 1 month in completely spinal cord transected (Th9/10) mice. CONCLUSION: These data reveal that many changes in mice and humans are comparable suggesting, in turn, that this model may be a valuable tool for neuroscientists to investigate the specific mechanisms associated with rapid health degradation post-SCI.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17876343/