Peer-reviewed veterinary case report
Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?
- Journal:
- Fertility and sterility
- Year:
- 2008
- Authors:
- Kaya, Hakan et al.
- Affiliation:
- Department of Obstetrics and Gynecology
- Species:
- rodent
Abstract
The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S1P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17517398/