Peer-reviewed veterinary case report
Disseminatedinfection in a dog with severe colitis.
- Journal:
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Year:
- 2020
- Authors:
- Curtis, Benjamin et al.
- Affiliation:
- Department of Microbiology · United States
- Species:
- dog
Plain-English summary
A 12-year-old spayed female Schipperke dog had a long-standing issue with inflammatory bowel disease and was experiencing severe colitis, which is inflammation of the colon, for two months. Despite treatment with medications like prednisolone and dexamethasone, her condition worsened, leading to liver disease, pneumonia, and skin infections. Tests showed that she had severe damage in her colon and other organs, with signs of a parasitic infection. Unfortunately, the use of immunosuppressive drugs may have allowed the infection to spread throughout her body. Sadly, the treatment did not work, and her condition was severe at the time of examination.
Abstract
A 12-y-old spayed female Schipperke dog with a previous diagnosis of inflammatory bowel disease was presented with a 2-mo history of severe colitis. The patient's condition progressed to hepatopathy, pneumonia, and dermatitis following management with prednisolone and dexamethasone sodium phosphate. Colonic biopsies identified severe necrosuppurative colitis with free and intracellular parasitic zoites. Postmortem examination confirmed extensive chronic-active ulcerative colitis, severe acute necrotizing hepatitis and splenitis, interstitial pneumonia, ulcerative dermatitis, myelitis (bone marrow), and mild meningoencephalitis with variable numbers of intracellular and extracellular protozoal zoites. PCR on samples of fresh colon was positive for. Immunohistochemistry identifiedtachyzoites in sections of colon, and a single tissue cyst in sections of brain. Administration of immunosuppressive drugs may have allowed systemic dissemination offrom the intestinal tract.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32954990/