Peer-reviewed veterinary case report
Digital Outcome Measures for Gait and Spontaneous Locomotor Activity in Dystrophic Dogs.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2026
- Authors:
- Kuraoka, Mutsuki et al.
- Affiliation:
- Nippon Veterinary and Life Science University · Japan
- Species:
- dog
Abstract
Digital outcome measures utilizing digital devices and instruments are highly effective in capturing significant changes quantitatively in clinical trials of patients with Duchenne muscular dystrophy. A dystrophic model of beagle dogs, known as canine X-linked muscular dystrophy in Japan (CXMD), shows the symptoms of muscle weakness and has been evaluated for motor function using these digital outcome measures to assess therapeutic efficacy and monitor disease progression circumstantially. Here, we present accelerometry methods for analyzing gait function and infrared monitoring analysis for assessing spontaneous locomotor activity in CXMDdystrophic dogs. The multiple parameters derived from these methods can provide valuable phenotypic information in medium-to-large-sized experimental animals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41028688/