Peer-reviewed veterinary case report
Differential miRNA expression profiling of highly pathogenic avian influenza virus H5N1 infected chicken lungs reveals critical microRNAs, biological pathways and genes involved in the molecular pathogenesis.
- Journal:
- Virologica Sinica
- Year:
- 2022
- Authors:
- Mishra, Anamika et al.
- Affiliation:
- ICAR-National Institute of High Security Animal Diseases · India
- Species:
- bird
Abstract
• Highthrouput sequencing of small RNA of H5N1 infected and mock infected chicken lungs. • 297 miRNAs identified in mock-infected and 201 miRNAs identified in AIV infected chicken lungs. • 36 miRNAs were upregulated and 90 were downregulated during H5N1 infection. • Functional analysis and gene ontology of predicted target genes of expressed miRNAs. • MAPK pathway, NF-κB, IGF and gga-let-7b might play important role during H5N1 pathogenesis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/35278696/