Peer-reviewed veterinary case report
Dexmedetomidine alleviates lipopolysaccharide-induced lung injury in Wistar rats.
- Journal:
- Oncotarget
- Year:
- 2017
- Authors:
- Yan, Xuetao et al.
- Affiliation:
- Department of Anesthesiology · China
- Species:
- rodent
Abstract
This study aimed to investigate the protective effects of dexmedetomidine on lipopolysaccharide (LPS)-induced lung injury in Wistar rats. 24 female Wistar rats were randomly assigned into 3 groups (n = 8): a control group, a LPS-challenged group, and a LPS plus dexmedetomidine group. Inflammation, oxidative stress, Nrf2/Keap1, and Akt signal were determined. The results showed that LPS caused inflammation and oxidative stress via increasing pro-inflammatory cytokines and oxidative products. Dexmedetomidine treatment alleviated inflammation and oxidative stress in LPS-challenged rats. Nrf2/Keap1 was inhibited and Akt signal was activated in the lung after exposure to LPS, while dexmedetomidine activated Nrf2/Keap1, which further mediated expressions of antioxidant genes. In conclusion, dexmedetomidine alleviated inflammatory response and oxidative stress in LPS-induced lung injury in rats via influencing Nrf2/Keap1 signal.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28574842/