Peer-reviewed veterinary case report
Decreased proliferation ability and differentiation potential of mesenchymal stem cells of osteoporosis rat.
- Journal:
- Asian Pacific journal of tropical medicine
- Year:
- 2014
- Authors:
- Wang, Qiang et al.
- Affiliation:
- 2nd Department of Orthopaedic Surgery · China
- Species:
- rodent
Abstract
OBJECTIVE: To explore decreased proliferation ability and differentiation potential of mesenchymal stem cells (MSCs) of osteoporosis rat. METHODS: MSCs were obtained from osteoporosis rat, and proliferation potency and impaired osteogenic differentiation potential were determined. RESULTS: The result showed a significant downregulation of MSCs pluripotency related gene (Oct 4) and osteogenic genes (BSP, OCN) expression in OVX MSCs compared with Sham MSCs (P<0.05). CONCLUSIONS: These data suggest that MSCs are aging in osteoporosis body, and autologous OVX MSCs transplantation is not appropriate to treat osteoporosis if necessary. There will be a possibility in establishing a new clinical application of MSCs autologous transplantation to treat osteoporosis, if OVX MSCs have stronger proliferation and differentiation.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25063060/