Peer-reviewed veterinary case report
Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide.
- Journal:
- Inflammation research : official journal of the European Histamine Research Society ... [et al.]
- Year:
- 2012
- Authors:
- Dubayle, David & Héron, Anne
- Affiliation:
- Paris Descartes University · France
- Species:
- rodent
Abstract
INTRODUCTION: The mast cell is an immunocyte, but its functions in the brain remain unclear. MATERIALS AND METHODS: In a rat model of weak inflammation, we analyzed the effect of a gram-negative bacterial lipopolysaccharide injection (100 μg/kg) on thalamic mast cell (MC) population. CONCLUSION: We demonstrate a significant decrease of their degranulation, which suggests the implication of MC in preventing sepsis on the brain.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23080081/