Peer-reviewed veterinary case report
Curcumin nanogel and its efficacy against oxidative stress and inflammation in rat models of ischemic stroke.
- Journal:
- Nanomedicine (London, England)
- Year:
- 2024
- Authors:
- Khuwaja, Gulrana et al.
- Affiliation:
- Department of Pharmaceutical Chemistry & Pharmacognosy
- Species:
- rodent
Abstract
The study was designed to develop and analyze curcumin nanoparticles.Curcumin nanoparticles were formulated and evaluated. Their efficacy in protecting against brain damage was investigated in a rat model of ischemic stroke, considering motor function, muscle strength and antioxidant enzyme activity.Curcumin nanoparticles displayed a zeta potential of -55 ± 13.5 mV and an average particle size of 51.40 ± 21.70 nm. In ischemic stroke rat models, curcumin nanoparticle treatment significantly improved motor functions, and muscle strength and increased the activities of antioxidant enzymes like glutathione peroxidase, glutathione, glutathione S-transferase, superoxide dismutase and catalase, reducing oxidative stress and inflammation.Curcumin nanoparticles showed significant neuroprotective effects in ischemic stroke models.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38661738/