Peer-reviewed veterinary case report
Congenic strain differences of renal malformations in ACI/Mna rats by introgression of the chromosomal region of BUF/Mna rats containing Pur1.
- Journal:
- Nagoya journal of medical science
- Year:
- 2013
- Authors:
- Matsuyama, Mutsushi et al.
- Species:
- rodent
Abstract
The ACI rats developed hereditary renal malformations including agenesis and hydronephrosis at moderate penetrance. During construction of a variety of congenic strains based on ACI/Mna (ACI), BUF/Mna (BUF), and WKY/NCrj (WKY) rats, we found that the renal malformations were significantly suppressed by introgression of a segment of chromosome 13 of BUF rats containing Pur1 locus. It is plausible that this region contain a modifier locus influencing development of renal malformations.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24640181/