Comparison of the alkalizing abilities between 1.35% sodium bicarbonate solutions with and without dextrose in healthy calves.

Abstract

The present study aimed to clarify the alkalizing ability of 1.35% isotonic sodium bicarbonate solution (ISBS), which did not contain dextrose, compared with that of 1.35% isotonic bicarbonate sodium solution containing 4.03% dextrose (ISBD) in healthy calves. The calves were intravenously administered with 20.7 mL/kg of the solutions for 30 min as the volume required to correct base deficit of 10 mM. ISBS increased the blood pH, HCO, and base excess from 7.44 &#xb1; 0.02, 29.6 &#xb1; 1.9 mM, and 5.3 &#xb1; 2.1 mM to 7.49 &#xb1; 0.02, 36.9 &#xb1; 2.3 mM, and 13.5 &#xb1; 2.6 mM respectively (P<0.05). These factors for the ISBD group increased from 7.41 &#xb1; 0.02, 29.0 &#xb1; 1.1 mM, and 4.5 &#xb1; 1.3 mM to 7.43 &#xb1; 0.02, 33.5 &#xb1; 1.9 mM, and 9.5 &#xb1; 1.7 mM (P<0.05), respectively. Furthermore, in the ISBD group, the relative plasma volume and blood glucose level increased while the Klevel decreased, which did not occur in the ISBS group. Therefore, the results revealed that ISBS had better alkalizing ability in calves than ISBD.