COMPARATIVE EXPERIMENTAL STUDY OF MORPHOLOGICAL CHANGES IN THE KIDNEY IN ACUTE OBSTRUCTIVE PYELONEPHRITIS MODEL: INFLUENCE OF INFECTION ROUTE.

Abstract

BACKGROUND: The objective of this study is to conduct a comparative morphological analysis of the kidneys in the context of various infection pathways in models of acute obstructive pyelonephritis. METHODS: The study investigated the structural condition of rabbit kidneys (n=40) in relation to the pathogenesis of acute pyelonephritis. The animals were randomly assigned to four groups: two experimental and two control groups. Experimental Groups I and II underwent urethral ligation to induce obstructive pyelonephritis. In Group I, a bacterial strain was introduced into the gastrointestinal tract to examine intestinal translocation, while in Group II, it was introduced into the urinary bladder to study ascending infection. Control Groups III and IV received a similar introduction of the infectious agent without urethral obstruction. On the third day, morphological examination was conducted using optical microscopy and a computerized microscope capable of digital microphotography. RESULTS: In Group I, inflammatory changes were detected in 60% of cases, while in Group II, they were found in 70% of cases. No morphological changes were observed in the control groups. CONCLUSION: The nature of morphological changes in the kidneys in the model of acute obstructive pyelonephritis did not show statistically significant differences when comparing between the experimental groups. This indicates the involvement of enterorenal bacterial translocation in the development of inflammatory processes in the kidneys in the presence of obstruction.