Peer-reviewed veterinary case report
Combined Effect of Bone Morphogenetic Protein-2 and Erythropoietin on Regeneration of Cranial Bone Defects in Mice.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2019
- Authors:
- Gromov, A V et al.
- Affiliation:
- N. F. Gamaleya National Research Center of Epidemiology and Microbiology
- Species:
- rodent
Abstract
Using mouse model of regeneration of critical size cranial defects, we studied combined effect of 1 and 10 μg of BMP-2 of prokaryotic origin and recombinant erythropoietin (Epostim) injected subcutaneously in the area of bone defect in a total dose of 6000 U/kg. Erythropoietin considerably improved quantitative and qualitative characteristics of the bone tissue in the site of implantation when used in combination with BMP-2 in both concentrations.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31350656/