Peer-reviewed veterinary case report
Coherence analysis over the latent period of epileptogenesis reveal that high-frequency communication is increased across hemispheres in an animal model of limbic epilepsy.
- Journal:
- Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
- Year:
- 2006
- Authors:
- Simonotto, Jennifer D et al.
- Affiliation:
- Department of Biomedical Engineering · United States
- Species:
- rodent
Abstract
A total of 32 microwire electrodes were implanted bilaterally into the hippocampus of Sprague-Dawley rats, which were then stimulated in the manner prescribed for the chronic limbic epilepsy model. After the initial seizure brought on by the stimulation, the animals were recorded at a high sampling rate (approximately 12 kHz) for the entire duration of the latent period. Coherence was calculated across channels in both stimulated (and later seizing) animals and non-stimulated (and thus non-seizing control) animals. Average coherence over time was greatest in intrahemispherical electrode pairs in both stimulated and non-stimulated animals. However, the 200-800 Hz band displays increased coherence interhemispherically and up to 200 Hz band displays decreased coherence interhemispherically: this occurs only in stimulated animals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17946026/