Peer-reviewed veterinary case report
Cognitive-performance recovery of Alzheimer's disease model mice by modulation of early soluble amyloidal assemblies.
- Journal:
- Angewandte Chemie (International ed. in English)
- Year:
- 2009
- Authors:
- Frydman-Marom, Anat et al.
- Affiliation:
- Department of Molecular Microbiology and Biotechnology
- Species:
- rodent
Abstract
A rationally designed oligomerization inhibitor interacts with early intermediate assemblies of amyloid-beta polypeptide (Abeta) through the aromatic elements and inhibits their assembly into the toxic oligomers that cause Alzheimer's disease by a unique C(alpha)-methylation beta-breakage strategy. The electrostatic potential of the low-energy conformation of the dipeptide inhibitor bound to Abeta is shown.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19035593/