Peer-reviewed veterinary case report
Clinical diabetes mellitus in association with diestrus-induced acromegaly in 2 bitches.
- Journal:
- Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
- Year:
- 2019
- Authors:
- Cui, Yi et al.
- Affiliation:
- Department of Veterinary Clinical Sciences
- Species:
- dog
Plain-English summary
Two female dogs, aged 9 and 11 years, were brought to the vet because they were drinking and urinating a lot, vomiting, eating less than usual, and seemed very tired. During the examination, the vet noticed signs of tissue overgrowth, like large paws and a wider space between their teeth. One dog was diagnosed with diabetes mellitus (a condition where the body can't properly manage sugar levels), while the other had a more severe form called diabetic ketoacidosis. Tests showed that both dogs had hormonal changes linked to their reproductive cycle, which contributed to their conditions. After surgery to remove their ovaries and uterus, one dog showed improvement in her diabetes, while the other had better control of her blood sugar levels. Overall, the treatment worked well for both dogs, leading to a good outcome.
Abstract
Two intact bitches aged 9 and 11 years were referred due to chronic polyuria, polydipsia, vomiting, anorexia and progressive lethargy. On clinical examination, signs of tissue overgrowth (large paws, widened interdental space, pharyngeal stridor) were noticed. Diabetes mellitus (DM) was diagnosed in one dog (case 1) and diabetic ketoacidosis (DKA) in the other (case 2). There were increased IGF-1 values suggestive of hypersomatotropism. Progesterone values and pathological findings of the ovaries and uterus indicated diestrus. Diagnosis of diestrus-induced hypersomatotropism was made and ovariohysterectomy was performed in both dogs. Dog 1 also had multiple mammary neoplasms treated with bilateral mastectomy. Treatment resulted in diabetic remission in case 1 and improved glycaemic control in case 2. Overall, diestrus-induced hypersomatotropism is rare but should be considered in any intact diabetic bitch with acromegalic features. Ovariohysterectomy is recommended and associated with a fair to good prognosis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31212352/