Peer-reviewed veterinary case report
Clinical and pathological characterization of a feline intestinal large granular lymphocyte lymphoma (LGLL).
- Journal:
- Veterinary research communications
- Year:
- 2025
- Authors:
- Amaral, Camila Issa et al.
- Affiliation:
- Departamento de Clí · Brazil
- Species:
- cat
Plain-English summary
A five-year-old neutered male domestic cat had been vomiting, eating less than usual, losing weight, and showing signs of abdominal pain for three months. An ultrasound showed that a part of his intestine was thicker than normal, which suggested a possible tumor. The vet performed surgery to remove part of the intestine and sent the tissue for further examination. The results showed a mass in the intestine made up of unusual cells, leading to a diagnosis of intestinal large granular lymphoma, a type of cancer. The outcome of the treatment is not mentioned, so it's unclear how the cat responded to the surgery.
Abstract
A five-year-old neutered male domestic cat presented with a three-month history of vomiting, hyporexia, progressive weight loss, and abdominal pain. Ultrasound revealed a significant increase in the thickness of the ileum, suggestive of a neoplastic process. Enterectomy and enteroanastomosis was performed, and the sample was sent for histopathological examination. Grossly, the intestine was tortuous and was irregular. In the antimesenteric portion, a 1.4 cm thick, annular, homogenous, white and soft mass was present slightly reducing luminal diameter. Histologically, the neoplastic cells were arranged in sheets of large and pleomorphic round cells with numerous intracytoplasmic eosinophilic granules extending from the lamina propria to the serosa. Tumor cell immunolabelling was for CD3, multifocal for granzyme B and absent for CD79a and CD20. Based on the morphology and immunophenotyping of the neoplastic cells, the diagnosis of intestinal large granular lymphoma was made.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40343496/