Peer-reviewed veterinary case report
Changes of the cortex proteome and Apolipoprotein E in transgenic mouse models of Alzheimer's Disease.
- Journal:
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
- Year:
- 2006
- Authors:
- Carrette, O et al.
- Affiliation:
- Department of Structural Biology and Bioinformatics
- Species:
- rodent
Abstract
Transgenic mice carrying human Amyloid Precursor Protein mutations present amyloid plaque deposition in the brain upon aging. In this study, we characterized the changes of cortex proteome and endogenous Apolipoprotein E in these mice. Differential analysis of two-dimensional electrophoresis images revealed spots altered upon aging, transgene addition and plaque deposition. Alpha-synuclein and cytochrome oxidase polypeptide Va were up-regulated in transgenic mice. Upon aging, expression of ATP synthase alpha, alpha enolase, UMP-CMP kinase, and dihydropyrimidinase like-2 protein was modified. These proteins and their modification probably play a role in the amyloid aggregate formation in these mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16781898/