Peer-reviewed veterinary case report
Cell-based therapies: current issues and future directions.
- Journal:
- The Veterinary clinics of North America. Equine practice
- Year:
- 2011
- Authors:
- Stewart, Matthew C
- Affiliation:
- Department of Veterinary Clinical Medicine · United States
- Species:
- horse
Plain-English summary
This article discusses the challenges and future possibilities of using cell-based therapies, like stem cells, to treat muscle and joint problems in horses. It highlights the need to better understand where to get these stem cells from and how to use them effectively. The authors also talk about the potential benefits of using stem cells from embryos and the importance of making sure these treatments work well without complicated preparation. Overall, the article emphasizes the need for more research to prove that these therapies are effective for horses.
Abstract
This article focuses on current issues facing cell-based therapies in equine practice and future studies validating the use of stem cells and related biologic therapies for the treatment of musculoskeletal conditions in the horse. Issues raised include the characterization and use of tissue- and anatomic location-specific mesenchymal stem cell (MSC) sources, the putative advantages and feasibility of allogeneic embryonic stem cell and MSC products, the technical advantages and performance of cell-based biologic agents that do not require extensive ex vivo manipulation, the regulation of MSC homing, potential nonorthopaedic stem cell applications, and the logistics required to demonstrate cell-based therapy efficacy in horses.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21872767/