Peer-reviewed veterinary case report
Celastrol treatment attenuates the inflammatory response in Alzheimer's disease model mice.
- Journal:
- Neurological research
- Year:
- 2026
- Authors:
- Cao, Fanfan et al.
- Affiliation:
- Department of Central Laboratory · China
- Species:
- rodent
Abstract
OBJECTIVE: Alzheimer's disease (AD) is the most common neurodegenerative disease. Unfortunately, current effective therapeutics for AD are limited, and thus, the discovery of novel anti-AD agents is urgently needed. Celastrol, a plant-derived triterpene, has both antioxidant and anti-inflammatory activities. METHODS AND RESULTS: Here, we found that celastrol treatment promoted microglial M2 polarization and inhibited inflammatory factor expression in bothandexperiments. Celastrol treatment significantly improved cognitive function in AD mice by regulation the TLR4/NFκB pathway, overexpression TLR4 reversed the protective effect of CEL to cognitive function in AD model mice. Suggesting that TLR4/NFκB plays a crucial role in regulating the inflammatory response. CONCLUSION: Taken together, the results indicate that celastrol treatment attenuated the inflammatory response in AD mice by promoting microglial M2 polarization via the TLR4/NFκB pathway.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40762111/