Peer-reviewed veterinary case report
CD4-HIV-1 Envelope Interactions: Critical Insights for the Simian/HIV/Macaque Model.
- Journal:
- AIDS research and human retroviruses
- Year:
- 2018
- Authors:
- Sharma, Amit & Overbaugh, Julie
- Affiliation:
- 1 Division of Human Biology · United States
Abstract
The macaque models of HIV-1 infection have been a cornerstone of research on transmission, pathogenesis, and prevention. In particular, the infection of macaques with chimeric simian/HIV-1 viruses (SHIVs) is central to the vaccine development pipeline because SHIVs encode the key target of HIV-1-neutralizing antibodies, the HIV-1 envelope (env) protein. In this review, we highlight some of the recent studies that have improved our understanding of the CD4-HIV-1 env interaction, which are crucial for development of SHIV/macaque models of HIV-1 infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29886767/