Peer-reviewed veterinary case report
CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke.
- Journal:
- Metabolic brain disease
- Year:
- 2011
- Authors:
- Ren, Xuefang et al.
- Affiliation:
- 3710 SW US Veterans Hospital Rd. · United States
- Species:
- rodent
Abstract
Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25+Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3(DTR) mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21082336/