Peer-reviewed veterinary case report
CCH cells are potent stimulators in the allogeneic mixed leucocyte reaction.
- Journal:
- Veterinary immunology and immunopathology
- Year:
- 2007
- Authors:
- Baines, S J et al.
- Affiliation:
- University of Cambridge · United Kingdom
- Species:
- dog
Abstract
Canine cutaneous histiocytoma (CCH) has been identified as a tumour of epidermal Langerhans cells (LCs) on the basis of immunophenotypic studies. Neoplastic Langerhans cells (CCH-LCs) were isolated from lesions of canine cutaneous histiocytoma. The CCH-LC cells expressed CD1b, CD11/18, CD45, MHC-I, and MHC-II. The CCH-LC cells were potent stimulators of the mixed leucocyte reaction (MLR) in vitro when compared to PBMCs from the tumour-bearing animals. This provides evidence that the neoplastic cells in CCH have functional as well as immunophenotypic characteristics of Langerhans cells.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17675250/