Peer-reviewed veterinary case report
Canine Parvovirus Infection Potentiates Canine Distemper Encephalitis Attributable to Modified Live-Virus Vaccine
- Journal:
- Journal of the American Veterinary Medical Association
- Year:
- 1982
- Authors:
- Krakowka, Steven et al.
- Affiliation:
- From the Department of Veterinary Pathobiology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210. · United States
- Species:
- dog
Abstract
SUMMARY Twelve gnotobiotic dogs from 2 litters were allotted to 3 groups. Group A dogs received a modified-live polyvalent (canine distemper, adenovirus type 2, and parainfluenza viruses and Leptospira canicola-icterohemorrhagiae bacterin) vaccine 3 days prior to oral inoculation with canine parvovirus (cpv). Group B dogs received cpv alone. Group C dogs received 1 dose of vaccine only. In none of the 9 cpv-inoculated dogs did clinical signs of cpv infection develop, although high serum antibody titers for cpv developed in all of them. However, in 2 of the 5 cpv-inoculated vaccinates, canine distemper virus encephalomyelitis subsequently developed. The results suggested that cpv exerts an immunomodulating effect on canine immune responses and may be responsible for vaccination failures in dogs.
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Search related cases →Original publication: https://doi.org/10.2460/javma.1982.180.02.137