Peer-reviewed veterinary case report
Braking bad: blockade of inhibitory pathways improves interleukin-15 therapy.
- Journal:
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Year:
- 2010
- Authors:
- Carson, William E
- Affiliation:
- Ohio State University Comprehensive Cancer Center · United States
- Species:
- rodent
Abstract
Blockade of the CTLA-4 and PD-1 inhibitory pathways in T cells via the administration of neutralizing antibodies at the time of interleukin (IL)-15 therapy markedly enhanced the survival of tumor-bearing mice as compared with those receiving IL-15 alone or IL-15 in combination with just one of the antibodies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21037024/