Peer-reviewed veterinary case report
Biomarkers for chronic kidney disease in dogs: a comparison study.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2020
- Authors:
- Kim, Joonyoung et al.
- Affiliation:
- Department of Veterinary Internal Medicine · South Korea
- Species:
- dog
Plain-English summary
This study looked at whether certain blood markers, specifically symmetric dimethylarginine (SDMA) and cystatin C (CysC), can help detect early kidney problems in dogs. Researchers examined 41 dogs with chronic kidney disease (CKD) who were stable and compared them to 10 healthy beagles. They found that both SDMA and CysC levels were higher in the dogs with CKD, but CysC was particularly good at identifying the very early stages of the disease. Overall, CysC was more reliable than the other markers for spotting early kidney issues. The findings suggest that CysC could be a useful tool for veterinarians in diagnosing early CKD in dogs.
Abstract
The aim of this study was to determine whether serum symmetric dimethylarginine (SDMA) and cystatin C (CysC) levels can be utilized as more accurate markers of early kidney dysfunction in dogs. Forty-one client-owned dogs with chronic kidney disease (CKD), which were clinically stable, and ten beagles as healthy controls were included. All dogs underwent physical examination, systemic blood pressure measurement, complete blood cell count, and plasma biochemistry analyses. Frozen serum was used for SDMA and CysC analyses. Data analysis was performed using Kruskal Wallis, Pearson's correlation, Bland-Altman plots, and receiver operating characteristic curve. SDMA and CysC levels were significantly higher in patients with CKD at various International Renal Interest Society (IRIS) stages than in the healthy controls. In particular, CysC level was the only biomarker that could indicate the earliest stage of CKD (IRIS stage I). Similar to these results, CysC level showed better sensitivity and specificity compared to the other biomarkers in early CKD dogs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32581150/