Peer-reviewed veterinary case report
Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007).
- Journal:
- Veterinary and comparative oncology
- Year:
- 2015
- Authors:
- Coyle, V J et al.
- Affiliation:
- College of Veterinary Medicine · United States
- Species:
- dog
Abstract
The purpose of this retrospective study was to describe the biological behaviour of canine mandibular osteosarcoma (OSA) and to examine factors for their impact on metastasis-free interval (MFI) and survival time (ST). Records from dogs treated with mandibulectomy for OSA (1999-2007) were reviewed. Archived tumour samples were evaluated for mitotic index (MI) and tumour grade. Fifty dogs were included, 21 received chemotherapy. Twenty-nine dogs (58%) developed metastatic disease. The median MFI was 627 days, and median ST was 525 days. In univariate analysis MI > 40 was prognostic for decreased MFI and ST. Grade also influenced MFI and ST, with 5/21 (24%) dogs with grade II/III tumours metastasis-free at one year versus 16/22 (72%) dogs with grade I tumours (P = 0.002); and 5/21 (24%) dogs with grade II/III tumours alive versus 17/22 (77%) dogs with grade I tumours (P = 0.001). In multivariate analysis, histological grade and adjuvant chemotherapy were prognostic for MFI and ST.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23410097/