Peer-reviewed veterinary case report
Beneficial effects of antibacterial peptide PR-39 in a neonatal murine model of endotoxic shock.
- Journal:
- The new microbiologica
- Year:
- 2004
- Authors:
- Delfino, D et al.
- Affiliation:
- Department of Experimental Pathology and Microbiology · Italy
- Species:
- rodent
Abstract
The lethal effects occurring in neonatal (< 24-h old) BALB/c mice after challenge with E. coli lipopolysaccharide (LPS) were significantly counteracted by pretreatment with antibacterial peptide PR-39. Neonatal mice protection was probably related to the depressive effect of PR-39 on production of TNF-alpha known to be the major mediator of the lethal effects of neonatal endotoxic shock. Indeed, TNF-alpha plasmatic levels were consistently lower in pups pretreated with PR-39 compared with controls. Administration 24 h after challenge was no longer effective. Although PR-39 and anti-TNF-alpha doses were ineffective alone, when combined at different ratios protected neonatal mice. The present experiments show the potential use of peptide PR-39 in preventing neonatal endotoxic shock.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15646051/