Peer-reviewed veterinary case report
Aquaporin-4-dependent edema clearance following status epilepticus.
- Journal:
- Epilepsy research
- Year:
- 2012
- Authors:
- Lee, Darrin J et al.
- Affiliation:
- Department of Neurological Surgery · United States
- Species:
- rodent
Abstract
We investigated the role of aquaporin-4 in the development of cerebral edema following kainic acid-induced status epilepticus (SE) using specific gravimetry and T2 MRI techniques at 6 h, 1 day, 4 days and 7 days after SE. Our results indicate significantly greater tissue edema and T2 MRI changes in AQP4(-/-) compared to AQP4(+/+) mice that peaks at about 1 day after SE (greater in hippocampus relative to cortex). These results have implications for the mechanisms of edema formation and clearance following intense seizure activity.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21996149/