Peer-reviewed veterinary case report
Aquaporin 3 inhibition attenuates imiquimod-induced psoriatic symptoms in a murine model.
- Journal:
- Molecular biology reports
- Year:
- 2025
- Authors:
- Okubo, Ryosuke et al.
- Affiliation:
- Department of Pharmacology · Japan
- Species:
- rodent
Abstract
BACKGROUND: Aquaporin 3 (AQP3) is highly expressed in both keratinocytes and T cells within psoriatic skin. Previous studies have demonstrated that AQP3 knockout mice show reduced development of psoriatic symptoms in murine models. This study aims to evaluate the effect of AQP3 inhibition on psoriasis progression. METHODS AND RESULTS: AQP3 conditional knockout mice were generated to assess the role of AQP3 expression in keratinocytes and T cells in psoriasis pathogenesis. In an imiquimod (IMQ)-induced psoriasis model, psoriatic symptoms were significantly reduced in mice with keratinocyte-specific AQP3 deletion. Additionally, AQP3 inhibition by administration of anti-AQP3 monoclonal antibody (mAb) effectively alleviated IMQ-induced psoriasis symptoms in wild-type mice. CONCLUSIONS: AQP3 inhibition presents a promising approach for the treatment of psoriasis.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40167833/