Peer-reviewed veterinary case report
Application of faecal metabonomics on an experimental model of tubulointerstitial fibrosis by ultra performance liquid chromatography/high-sensitivity mass spectrometry with MS(E) data collection technique.
- Journal:
- Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
- Year:
- 2012
- Authors:
- Zhao, Ying-Yong et al.
- Affiliation:
- the College of Life Sciences · China
- Species:
- rodent
Abstract
Chronic renal failure (CRF) is a major challenge for the public healthcare problem. A novel UPLC Q-TOF/MS method with MS(E) data collection mode was developed as a very effective biochemical analytical tool for precise identification of important biomarkers in the adenine-induced CRF rats. Nine endogenous metabolites were identified by using metabonomic method combined with multivariate data analysis, the accurate mass, isotopic pattern, MS(E) fragments information and MassLynx i-FIT algorithm. The identified metabolites indicated the perturbations of bile acid and phospholipid metabolism are related to CRF rats. This work shows that metabonomics method is a valuable tool in CRF mechanism study.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23020077/