Peer-reviewed veterinary case report
Anxiolytic-like effect of Aronia melanocarpa fruit juice in rats.
- Journal:
- Methods and findings in experimental and clinical pharmacology
- Year:
- 2009
- Authors:
- Valcheva-Kuzmanova, S & Zhelyazkova-Savova, M
- Affiliation:
- Department of Preclinical and Clinical Pharmacology and Toxicology
- Species:
- rodent
Abstract
The main biologically active constituents of Aronia melanocarpa fruit juice (AMFJ) are polyphenolics, amongst them flavonoids, mainly anthocyanins. The aim of the present study was to investigate the effects of AMFJ (5 and 10 mL/kg) on anxiety using the social interaction test, on locomotor activity in the open field test and on working memory in the object recognition test in rats. AMFJ showed an anxiolytic-like effect which was demonstrated by a dose-dependent increase in the time of active social contacts between the test partners. The effects of both AMFJ doses were comparable to the effect of diazepam (1 mg/kg). AMFJ neither changed significantly horizontal and vertical locomotor activity, nor did it adversely affect working memory.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20140274/