Peer-reviewed veterinary case report
Antimicrobial dosing for common equine drugs: a content review and practical advice for veterinarians in Australia.
- Journal:
- Australian veterinary journal
- Year:
- 2019
- Authors:
- Hardefeldt, L Y et al.
- Affiliation:
- Faculty of Veterinary and Agricultural Science · Australia
- Species:
- horse
Plain-English summary
This study looked at how much of certain antibiotics should be given to adult horses to treat infections effectively and to avoid making these medications less effective over time. Researchers reviewed articles from various veterinary journals published between January 2015 and August 2018, focusing on the recommended doses for procaine penicillin G, gentamicin, and trimethoprim-sulfonamide. They found that the most common doses were 20,000 to 25,000 IU per kilogram for penicillin, 6.6 mg per kilogram for gentamicin, and 30 mg per kilogram for trimethoprim-sulfonamide. The study emphasizes that veterinarians in Australia need to stay updated on these dosing guidelines to ensure successful treatment and maintain the effectiveness of these antibiotics in the future.
Abstract
BACKGROUND: Appropriate dosing with antimicrobial agents is critical for effective treatment and to prevent the development of antimicrobial resistance. METHODS: A review was undertaken of equine journal articles (Equine Veterinary Journal, Equine Veterinary Education, Australian Veterinary Journal, Australian Equine Veterinarian, Journal of Veterinary Internal Medicine and Journal of Equine Veterinary Science) between January 2015 and August 2018. Those with dosing regimens for procaine penicillin G, gentamicin or trimethoprim-sulfonamide in adult horses were examined and evaluated. Pharmacokinetics and -dynamics of these drugs were also reviewed. RESULTS & CONCLUSION: The most frequently reported doses for penicillin, gentamicin and trimethoprim-sulfonamide were 20-25,000 IU/kg, 6.6 mg/kg and 30 mg/kg, respectively. Veterinarians treating equine patients in Australia should be aware of the current recommended doses and inter-dosing intervals to ensure efficacy in therapy and to preserve the usefulness of these antimicrobials for the future.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30919436/