Peer-reviewed veterinary case report
Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats.
- Journal:
- Indian journal of experimental biology
- Year:
- 2005
- Authors:
- Kumar, G et al.
- Affiliation:
- Department of Life Science · India
- Species:
- rodent
Abstract
Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the beta-carotene (BC). This supplementation reversed the trend inducing a significant decrease in bilirubin and urea levels. Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R). Pretreatment of rats with BC significantly increased the enzyme activities. The results suggest hepatoprotective activity of BC.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15875720/