Peer-reviewed veterinary case report
Antigenic variability of foot-and-mouth disease virus serotype O during serial cytolytic passage.
- Journal:
- Virus genes
- Year:
- 2017
- Authors:
- Subramaniam, Saravanan et al.
- Affiliation:
- ICAR-Directorate on Foot-and-Mouth Disease · India
Abstract
The emergence and disappearance of antigenic variants of foot-and-mouth disease virus (FMDV) during a field outbreak occurs periodically due to the volatile nature of its genome. In the present analysis, change in antigenic behavior of serotype O FMDV during the serial cytolytic passage in the absence of immune pressure was observed. Initially, the isolate showed a poor antigenic match (relationship value <0.3) with the serotype O vaccine strain and upon serial passage increase in relationship value was observed. Comparison of capsid sequence revealed substitution at four positions (VP3:K → E and P → S, VP1:E → K and R → Q) acquired during the serial passage. Examination of passage level and amino acid substitution revealed the critical role of position VP3-58 that was identified earlier as crucial for antigenic site IV, in the observed antigenic variability. The role of position VP3-58 was further confirmed using reverse genetics approach.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28718047/