Peer-reviewed veterinary case report
An immunohistochemical study of three equine pulmonary granular cell tumors.
- Journal:
- Veterinary pathology
- Year:
- 1995
- Authors:
- Bouchard, P R et al.
- Affiliation:
- Product Safety Assessment · United States
- Species:
- horse
Plain-English summary
This study looked at three cases of granular cell tumors (GCTs) in older horses, specifically in their lungs. These tumors were examined using special tests that help identify the types of cells involved. The tests showed that the tumors had strong reactions for certain proteins, indicating they likely come from similar cells as GCTs found in humans and rats. Overall, the findings suggest that these equine pulmonary GCTs are likely derived from neural crest cells, similar to those in other species.
Abstract
Granular cell tumor (GCT) is a morphologic designation for tumors of varied histogenesis. Most GCTs in human beings are derived from Schwann cells, and rat meningeal GCTs are believed to originate in the neural crest. Three equine pulmonary GCTs from aged horses were studied immunohistochemically with primary antibodies directed against vimentin, cytokeratins (AE1/AE3), S-100, Leu 7, desmin, and neuron-specific enolase (NSE) using a steptavidin-biotin procedure. All three tumors stained similarly with strong and diffuse staining of neoplastic cells for vimentin and S-100 and negative staining with all other antibodies. On the basis of the immunohistochemical results and the previously described histologic and ultrastructural characteristics, equine pulmonary GCT is designated as neural crest and possibly Schwann cell derived, similar to GCT in rats and human beings.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/8592814/