Peer-reviewed veterinary case report
Ameliorative effects ofandon letrozole induced polycystic ovary syndrome in Wistar rats.
- Journal:
- Redox report : communications in free radical research
- Year:
- 2021
- Authors:
- Kausar, Firdaus et al.
- Affiliation:
- Department of Ilmul Advia · India
- Species:
- rodent
Abstract
OBJECTIVES: The current study was designed to examine the therapeutic role of hydroalcoholic extract ofRoxb (CRE) andC.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats. METHODS: PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 weeks. Vaginal smears for phase of estrous cycle determination, serum levels of sex androgens, lipid profile, oxidative stress parameters and histopathology of ovarian tissues were investigated. RESULTS: Diestrous cycle days treated with CRE (group III) or PGE (group IV) decreased significantly ( < 0.05) compared to PCOS control animals (group II). Moreover, weight of uteri in PCOS animals treated with the plant extracts also increased significantly ( < 0.05) compared to that of group II animals. Histopathological examination showed the protective effect of the CRE and PGE indicated by the disappearance of ovarian cyst. CONCLUSION: The study demonstrated that the CRE and PGE either alone or in combination hold a significant effect in letrozole induced PCOS rat models and could be useful in the management of reproductive and metabolic disorders related to PCOS.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34018905/