Algorithmic approaches in hand imaging for rheumatic musculoskeletal diseases: A systematic literature review.

Abstract

<h4>Objective</h4>This systematic literature review provides a comprehensive overview of the use of machine learning (ML) in hand imaging of rheumatic musculoskeletal diseases (RMDs). The review evaluates ML algorithms, imaging modalities, patient populations, validation methods, and areas for improvement.<h4>Methods</h4>The review was conducted following PRISMA guidelines and registered with PROSPERO. Articles were retrieved from PubMed, EMBASE, and Scopus using relevant MeSH terms and keywords. The search, executed in October 2024, was conducted manually and with BiBot, an AI-based tool for literature reviews. Studies focusing on ML applications in osteoarthritis (OA), rheumatoid arthritis (RA), and psoriatic arthritis (PsA) were included.<h4>Results</h4>From 400 initially identified studies, 32 met the inclusion criteria. RA was the most studied disease (88 %), followed by OA (22 %) and PsA (9 %). Convolutional neural networks (CNNs) were the most frequently used algorithms (50 %). Standard radiographs (59 %) were the predominant imaging modality, followed by MRI (16 %). Despite recommendations for ML studies, external validation was conducted in only 15 % of studies, and just 6 % of datasets were publicly available. Interpretability tools were employed in 28 % of studies to enhance clinical relevance.<h4>Conclusion</h4>ML has significant potential to improve diagnostics and disease management in hand imaging of RMDs. However, key challenges remain, including the need for increased external validation, broader disease coverage (OA and PsA), and improved data-sharing practices to enhance reproducibility and clinical adoption.