Peer-reviewed veterinary case report
AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4.
- Journal:
- Journal of medical primatology
- Year:
- 2010
- Authors:
- García, Anapatricia et al.
- Affiliation:
- Emory University · United States
Abstract
A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4(+) T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20412378/