Peer-reviewed veterinary case report
Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP.
- Journal:
- Pharmacological reports : PR
- Year:
- 2014
- Authors:
- Zavala-Tecuapetla, Cecilia et al.
- Affiliation:
- Department of Developmental Epileptology
- Species:
- rodent
Abstract
Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured. MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals. Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25150003/